Avastin: Avastin is an antibody to vascular endothelial growth factor (VEGF), a protein responsible for angiogenesis (new blood vessel growth). Because of Avastin's ability to bind to VEGF, the VEGF molecule is then unable to bind to its receptor and hence angiogenesis does not occur.
Avastin is approved as an anti-tumor medication for use in specific cancer types. Although Avastin is not approved by the FDA for ocular use, it has proved to be highly efficacious for use in cases of retinal or choroidal neovascularization and macular edema. It has been in routine use for eye disease "off label" since 2005.
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